1mwt Summary

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Structure of penicillin G acyl-Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r at 2.45 A resolution.

The structure was published by Lim, D. and Strynadka, N.C., in 2002 in a paper entitled "Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of penicillin-binding protein 2a.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A penicillin-binding protein 2a Q93IC2 (24-668) (Q93IC2_STAAU)search Staphylococcus aureussearch 97% 646 98%
B penicillin-binding protein 2a Q93IC2 (24-668) (Q93IC2_STAAU)search Staphylococcus aureussearch 97% 646 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q93IC2 (24 - 668) penicillin-binding protein 2a Staphylococcus aureus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q93IC2) Penicillin binding protein 2a (PBP2A), N-terminal domainsearch, Penicillin binding protein dimerisation domainsearch, beta-Lactamase/D-ala carboxypeptidasesearch NTF2-like; domain 1search, Penicillin-binding protein 2a (Domain 2)search, Penicillin-binding protein 2a; domain 3search, DD-peptidase/beta-lactamase superfamilysearch PF00905: Penicillin binding protein transpeptidase domainsearch, PF03717: Penicillin-binding Protein dimerisation domainsearch, PF05223: NTF2-like N-terminal transpeptidase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q93IC2) penicillin bindingsearch metal ion bindingsearch response to antibioticsearch

Chain InterPro annotation
A, B Penicillin-binding protein, transpeptidasesearch Penicillin-binding protein, dimerisation domainsearch NTF2-like N-terminal transpeptidasesearch Beta-lactamase/transpeptidase-likesearch