› 1mwp

X-ray diffraction
1.8Å resolution

N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN

Released:
DOI: 10.2210/pdb1mwp/pdb
PDB entry 1mwp coloured by chain, front view.
PDB entry 1mwp coloured by chain, side view.
PDB entry 1mwp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW
Nat Struct Biol 6 327-31 (1999)
PMID: 10201399

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-APP Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 11.05 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 28-123; Coverage: 13%)
Gene names: A4, AD1, APP
Sequence domains: Amyloid A4 N-terminal heparin-binding
Structure domains: Amyloidogenic glycoprotein, heparin-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 31.2Å b: 48.6Å c: 67.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.242
Expression system: Komagataella pastoris

Quick links

Citations

37 review citations

Amyloid precursor protein trafficking, processing, and function.
Thinakaran et al. (2008)
36 more

16 mentions without citation

The amyloid-beta precursor protein: integrating structure with biological function.
Reinhard et al. (2005)
15 more