1mw4 Summary


Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139

The structure was published by Ivancic, M., Daly, R.J., and Lyons, B.A., in 2003 in a paper entitled "Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Growth factor receptor-bound protein 7 and Receptor protein-tyrosine kinase erbB-2.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Growth factor receptor-bound protein 7 Q14451 (415-532) (GRB7_HUMAN)search Homo sapienssearch < 90% 120 100%
B Receptor protein-tyrosine kinase erbB-2 P04626 (1135-1144) (ERBB2_HUMAN)search Homo sapienssearch < 90% 10 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q14451 (415 - 532) Growth factor receptor-bound protein 7 Homo sapiens
P04626 (1135 - 1144) Receptor protein-tyrosine kinase erbB-2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A SH2 domainsearch