1mv9 Summary


Crystal Structure of the human RXR alpha ligand binding domain bound to the eicosanoid DHA (Docosa Hexaenoic Acid) and a coactivator peptide

The structure was published by Egea, P.F., Mitschler, A., and Moras, D., in 2002 in a paper entitled "Molecular Recognition of Agonist Ligands by RXRs" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely RXR retinoid X receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RXR retinoid X receptor P19793 (223-462) (RXRA_HUMAN)search Homo sapienssearch 98% 240 89%
B Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 84%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P19793 (223 - 462) RXR retinoid X receptor Homo sapiens
Q15596 (686 - 698) Nuclear receptor coactivator 2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P19793) Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch PF00104: Ligand-binding domain of nuclear hormone receptorsearch
B Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P19793) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch zinc ion bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear receptor coactivator Src-1search