1mv0 Summary

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NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC

The structure was published by Pineda-Lucena, A., Ho, C.S., Mao, D.Y., et al., Szyperski, T., Penn, L.Z., and Arrowsmith, C.H., in 2005 in a paper entitled "A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Myc proto-oncogene protein and Myc box-dependent-interacting protein 1.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Myc proto-oncogene protein P01106 (55-68) (MYC_HUMAN)search Homo sapienssearch < 90% 14 100%
B Myc box-dependent-interacting protein 1 O00499 (513-593) (BIN1_HUMAN)search Homo sapienssearch < 90% 81 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01106 (55 - 68) Myc proto-oncogene protein Homo sapiens
O00499 (513 - 593) Myc box-dependent-interacting protein 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Myc amino-terminal regionsearch
B SH3-domainsearch SH3 Domainssearch Variant SH3 domainsearch
Chain InterPro annotation
A
B Src homology-3 domainsearch Amphiphysinsearch