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NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC

Solution NMR
PDB entry 1mv0 coloured by chain, ensemble of 20 models, front view.
PDB entry 1mv0 coloured by chain, ensemble of 20 models, side view.
PDB entry 1mv0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: c-MYC-BIN1 complex
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Multimeric state: hetero dimer
Accessible surface area: 5872.25 Å2
Buried surface area: 1246.08 Å2
Dissociation area: 623.04 Å2
Dissociation energy (ΔGdiss): -3.64 kcal/mol
Dissociation entropy (TΔSdiss): 8.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126321
Complex Portal ID: CPX-514

Macromolecules

Myc proto-oncogene protein
Chain: A
Length: 14 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01106 (Residues: 70-83; Coverage: 3%)
Gene names: BHLHE39, MYC
Myc proto-oncogene protein in PDB entry 1mv0, assembly 1, front view.
Myc proto-oncogene protein in PDB entry 1mv0, assembly 1, side view.
Myc proto-oncogene protein in PDB entry 1mv0, assembly 1, top view.
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Myc box-dependent-interacting protein 1
Chain: B
Length: 81 amino acids
Theoretical weight: 9.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00499 (Residues: 513-593; Coverage: 14%)
Gene names: AMPHL, BIN1
Pfam: Variant SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Myc box-dependent-interacting protein 1 in PDB entry 1mv0, assembly 1, front view.
Myc box-dependent-interacting protein 1 in PDB entry 1mv0, assembly 1, side view.
Myc box-dependent-interacting protein 1 in PDB entry 1mv0, assembly 1, top view.
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