1muz Summary

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NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC

The structure was published by Pineda-Lucena, A., Ho, C.S., Mao, D.Y., et al., Szyperski, T., Penn, L.Z., and Arrowsmith, C.H., in 2005 in a paper entitled "A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Myc box dependent interacting protein 1. This molecule has the UniProt identifier O00499 (BIN1_HUMAN)search. The sample contained 81 residues which is < 90% of the natural sequence. Out of 81 residues 81 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Myc box dependent interacting protein 1 O00499 (513-593) (BIN1_HUMAN)search Homo sapienssearch < 90% 81 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O00499 (513 - 593) Myc box dependent interacting protein 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch Variant SH3 domainsearch
Chain InterPro annotation
A SH3 domainsearch Amphiphysinsearch