1muo Summary

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CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE

The structure was published by Cheetham, G.M.T., Knegtel, R.M.A., Coll, J.T., et al., Weber, P., Lippke, J.A., and Austen, D.A., in 2002 in a paper entitled "Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Aurora-related kinase 1. This molecule has the UniProt identifier O14965 (AURKA_HUMAN)search. The sample contained 297 residues which is < 90% of the natural sequence. Out of 297 residues 245 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Aurora-related kinase 1 O14965 (107-403) (AURKA_HUMAN)search Homo sapienssearch < 90% 297 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (107 - 403) Aurora-related kinase 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (O14965) protein phosphorylationsearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch