1mua Summary



The structure was published by Tweedy, N.B., Nair, S.K., Paterno, S.A., Fierke, C.A., and Christianson, D.W., in 1993 in a paper entitled "Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 256 residues which is 98% of the natural sequence. Out of 256 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (4-259) (CAH2_HUMAN)search Homo sapienssearch 98% 256 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (4 - 259) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch cytoplasmsearch plasma membranesearch cytosolsearch basolateral plasma membranesearch microvillussearch axonsearch apical part of cellsearch membranesearch extracellular vesicular exosomesearch extracellular spacesearch angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch small molecule metabolic processsearch bicarbonate transportsearch kidney developmentsearch secretionsearch odontogenesis of dentin-containing toothsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of bone resorptionsearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch response to estrogensearch morphogenesis of an epitheliumsearch response to organic substancesearch regulation of anion transportsearch response to pHsearch one-carbon metabolic processsearch carbon dioxide transportsearch response to zinc ionsearch positive regulation of cellular pH reductionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch