1mtc Summary

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GLUTATHIONE TRANSFERASE MUTANT Y115F

The structure was published by Codreanu, S.G., Ladner, J.E., Xiao, G., et al., Hachey, D.L., Gilliland, G.L., and Armstrong, R.N., in 2002 in a paper entitled "Local protein dynamics and catalysis: detection of segmental motion associated with rate-limiting product release by a glutathione transferase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glutathione S-transferase YB1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutathione S-transferase YB1 P04905 (2-218) (GSTM1_RAT)search Rattus norvegicussearch 100% 217 100%
B Glutathione S-transferase YB1 P04905 (2-218) (GSTM1_RAT)search Rattus norvegicussearch 100% 217 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04905 (2 - 218) Glutathione S-transferase YB1 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P04905) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P04905) response to metal ionsearch response to antibioticsearch response to axon injurysearch response to lithium ionsearch response to lead ionsearch sensory perception of smellsearch glutathione metabolic processsearch metabolic processsearch response to ethanolsearch response to drugsearch response to amino acidsearch response to stimulussearch protein homodimerization activitysearch steroid bindingsearch nickel cation bindingsearch glutathione transferase activitysearch transferase activitysearch extracellular regionsearch cytoplasmsearch protein complexsearch

Chain InterPro annotation
A, B Glutathione S-transferase, Mu classsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch