1mrv Summary


crystal structure of an inactive Akt2 kinase domain

The structure was published by Huang, X., Begley, M., Morgenstern, K.A., et al., Rose, P., Zhao, H., and Zhu, X., in 2003 in a paper entitled "Crystal structure of an inactive akt2 kinase domain" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of RAC-beta serine/threonine kinase. This molecule has the UniProt identifier P31751 (AKT2_HUMAN)search. The sample contained 339 residues which is < 90% of the natural sequence. Out of 339 residues 251 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RAC-beta serine/threonine kinase P31751 (143-481) (AKT2_HUMAN)search Homo sapienssearch < 90% 339 76%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P31751 (143 - 481) RAC-beta serine/threonine kinase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P31751) protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch