1mru Summary


Intracellular Ser/Thr protein kinase domain of Mycobacterium tuberculosis PknB.

The structure was published by Young, T.A., Delagoutte, B., Endrizzi, J.A., Falick, A.M., and Alber, T., in 2003 in a paper entitled "Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Probable serine/threonine-protein kinase pknB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Probable serine/threonine-protein kinase pknB P9WI81 (1-308) (PKNB_MYCTU)search Mycobacterium tuberculosis H37Rvsearch < 90% 311 87%
B Probable serine/threonine-protein kinase pknB P9WI81 (1-308) (PKNB_MYCTU)search Mycobacterium tuberculosis H37Rvsearch < 90% 311 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WI81 (1 - 308) Probable serine/threonine-protein kinase pknB Mycobacterium tuberculosis

Chain Structural classification (SCOP) Structural classification (CATH)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search

Chain ID Molecular function (GO) Biological process (GO)
A, B (P9WI81) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch