1mrq Summary


Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone

The structure was published by Couture, J.F., Legrand, P., Cantin, L., Luu-The, V., Labrie, F., and Breton, R., in 2003 in a paper entitled "Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.59 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Aldo-keto reductase family 1 member C1. This molecule has the UniProt identifier Q04828 (AK1C1_HUMAN)search. The sample contained 323 residues which is 100% of the natural sequence. Out of 323 residues 323 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Aldo-keto reductase family 1 member C1 Q04828 (2-323) (AK1C1_HUMAN)search Homo sapienssearch 100% 323 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q04828 (2 - 323) Aldo-keto reductase family 1 member C1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q04828) Aldo-keto reductases (NADP)search NADP-dependent oxidoreductasesearch PF00248: Aldo/keto reductase familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q04828) phototransduction, visible lightsearch cholesterol homeostasissearch oxidation-reduction processsearch bile acid metabolic processsearch response to organophosphorussearch retinal metabolic processsearch cellular response to jasmonic acid stimulussearch doxorubicin metabolic processsearch epithelial cell differentiationsearch retinoid metabolic processsearch bile acid and bile salt transportsearch intestinal cholesterol absorptionsearch protein homooligomerizationsearch daunorubicin metabolic processsearch progesterone metabolic processsearch digestionsearch xenobiotic metabolic processsearch oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorsearch androsterone dehydrogenase (B-specific) activitysearch bile acid bindingsearch aldo-keto reductase (NADP) activitysearch trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activitysearch carboxylic acid bindingsearch phenanthrene 9,10-monooxygenase activitysearch ketosteroid monooxygenase activitysearch alditol:NADP+ 1-oxidoreductase activitysearch oxidoreductase activitysearch 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activitysearch indanol dehydrogenase activitysearch extracellular vesicular exosomesearch cytoplasmsearch cytosolsearch

Chain InterPro annotation
A Aldo/keto reductasesearch Aldo/keto reductase, conserved sitesearch Aldo/keto reductase subgroupsearch NADP-dependent oxidoreductase domainsearch