1mro Summary

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METHYL-COENZYME M REDUCTASE

The structure was published by Ermler, U., Grabarse, W., Shima, S., Goubeaud, M., and Thauer, R.K., in 1997 in a paper entitled "Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.16 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely METHYL-COENZYME M REDUCTASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A METHYL-COENZYME M REDUCTASE P11558 (2-549) (MCRA_METTM)search Methanothermobacter marburgensis str. Marburgsearch 100% 548 100%
D METHYL-COENZYME M REDUCTASE P11558 (2-549) (MCRA_METTM)search Methanothermobacter marburgensis str. Marburgsearch 100% 548 100%
B METHYL-COENZYME M REDUCTASE P11560 (2-443) (MCRB_METTM)search Methanothermobacter marburgensis str. Marburgsearch 100% 442 100%
E METHYL-COENZYME M REDUCTASE P11560 (2-443) (MCRB_METTM)search Methanothermobacter marburgensis str. Marburgsearch 100% 442 100%
C METHYL-COENZYME M REDUCTASE P11562 (2-248) (MCRG_METTM)search Methanothermobacter marburgensis str. Marburgsearch 99% 247 100%
F METHYL-COENZYME M REDUCTASE P11562 (2-248) (MCRG_METTM)search Methanothermobacter marburgensis str. Marburgsearch 99% 247 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P11558 (2 - 549) METHYL-COENZYME M REDUCTASE Methanothermobacter marburgensis str. Marburg
P11560 (2 - 443) METHYL-COENZYME M REDUCTASE Methanothermobacter marburgensis str. Marburg
P11562 (2 - 248) METHYL-COENZYME M REDUCTASE Methanothermobacter marburgensis str. Marburg

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D (P11558) Methyl-coenzyme M reductase alpha and beta chain C-terminal domainsearch, Methyl-coenzyme M reductase alpha and beta chain N-terminal domainsearch Methyl-coenzyme M Reductase; Chain A, domain 1search, Alpha-Beta Plaitssearch, Methyl-coenzyme M Reductase; Chain B, domain 2search PF02249: Methyl-coenzyme M reductase alpha subunit, C-terminal domainsearch, PF02745: Methyl-coenzyme M reductase alpha subunit, N-terminal domainsearch
B, E (P11560) Methyl-coenzyme M reductase alpha and beta chain C-terminal domainsearch, Methyl-coenzyme M reductase alpha and beta chain N-terminal domainsearch Alpha-Beta Plaitssearch, Methyl-coenzyme M Reductase; Chain B, domain 2search PF02241: Methyl-coenzyme M reductase beta subunit, C-terminal domainsearch, PF02783: Methyl-coenzyme M reductase beta subunit, N-terminal domainsearch
C, F (P11562) Methyl-coenzyme M reductase gamma chainsearch Lambda Exonuclease; Chain Asearch PF02240: Methyl-coenzyme M reductase gamma subunitsearch

Chain ID Molecular function (GO) Biological process (GO)
A, D (P11558) coenzyme-B sulfoethylthiotransferase activitysearch transferase activitysearch metal ion bindingsearch methanogenesissearch
B, E (P11560) coenzyme-B sulfoethylthiotransferase activitysearch transferase activitysearch methanogenesissearch
C, F (P11562) transferase activitysearch coenzyme-B sulfoethylthiotransferase activitysearch methanogenesissearch

Chain InterPro annotation
A, D Methyl-coenzyme M reductase, alpha subunit, N-terminalsearch Methyl-coenzyme M reductase, alpha/beta subunit, C-terminalsearch Methyl-coenzyme M reductase, ferredoxin-like foldsearch Methyl-coenzyme M reductase, alpha subunit, C-terminalsearch Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 1search Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2search Methyl coenzyme M reductase, alpha subunitsearch Methyl-coenzyme M reductase, alpha/beta subunit, domain 2, C-terminalsearch
B, E Methyl-coenzyme M reductase, beta subunitsearch Methyl-coenzyme M reductase, alpha/beta subunit, C-terminalsearch Methyl-coenzyme M reductase, ferredoxin-like foldsearch Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2search Methyl-coenzyme M reductase, beta subunit, C-terminalsearch Methyl-coenzyme M reductase, beta subunit, N-terminalsearch Methyl-coenzyme M reductase, alpha/beta subunit, domain 2, C-terminalsearch
C, F Methyl-coenzyme M reductase, gamma subunitsearch Methyl-coenzyme M reductase, ferredoxin-like foldsearch