1mr1 Summary

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Crystal Structure of a Smad4-Ski Complex

The structure was published by Wu, J.-W., Krawitz, A.R., Chai, J., et al., Zhang, F., Luo, K., and Shi, Y., in 2002 in a paper entitled "Structural Mechanism of Smad4 Recognition by the Nuclear Oncoprotein Ski: Insights on Ski-mediated Repression of TGF-beta Signaling" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.85 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Mothers against decapentaplegic homolog 4 and Ski oncogene.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mothers against decapentaplegic homolog 4 Q13485 (319-552) (SMAD4_HUMAN)search Homo sapienssearch < 90% 235 82%
B Mothers against decapentaplegic homolog 4 Q13485 (319-552) (SMAD4_HUMAN)search Homo sapienssearch < 90% 235 82%
C Ski oncogene P12755 (219-313) (SKI_HUMAN)search Homo sapienssearch < 90% 99 97%
D Ski oncogene P12755 (219-313) (SKI_HUMAN)search Homo sapienssearch < 90% 99 97%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13485 (319 - 552) Mothers against decapentaplegic homolog 4 Homo sapiens
P12755 (219 - 313) Ski oncogene Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SMAD domainsearch Tumour Suppressor Smad4search MH2 domainsearch
C, D SMAD4-binding domain of oncoprotein Skisearch SAND domainsearch c-SKI Smad4 binding domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (Q13485) intracellularsearch regulation of transcription, DNA-templatedsearch
C, D (P12755) transcription, DNA-templatedsearch SMAD bindingsearch

Chain InterPro annotation
A, B SMAD domain, Dwarfin-typesearch SMAD/FHA domainsearch Dwarfinsearch SMAD domain-likesearch
C, D SAND domain-likesearch c-SKI SMAD4-binding domainsearch Transcription regulator SKI/SnoNsearch Ski oncogenesearch