1mq4 Summary

pdbe.org/1mq4
spacer

Crystal Structure of Aurora-A Protein Kinase

The structure was published by Nowakowski, J., Cronin, C.N., McRee, D.E., et al., Scheibe, D.N., Swanson, R.V., and Thompson, D.A., in 2002 in a paper entitled "Structures of the Cancer-Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AURORA-RELATED KINASE 1. This molecule has the UniProt identifier O14965 (AURKA_HUMAN)search. The sample contained 272 residues which is < 90% of the natural sequence. Out of 272 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AURORA-RELATED KINASE 1 O14965 (125-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 272 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (125 - 391) AURORA-RELATED KINASE 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O14965) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch mitotic cell cyclesearch protein phosphorylationsearch mitotic spindle organizationsearch regulation of signal transductionsearch cell cyclesearch meiotic spindle organizationsearch microtubule cytoskeleton organizationsearch meiotic cell cyclesearch mitotic centrosome separationsearch centrosome organizationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch