1mq4 Summary

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Crystal Structure of Aurora-A Protein Kinase

The structure was published by Nowakowski, J., Cronin, C.N., McRee, D.E., et al., Scheibe, D.N., Swanson, R.V., and Thompson, D.A., in 2002 in a paper entitled "Structures of the Cancer-Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AURORA-RELATED KINASE 1. This molecule has the UniProt identifier O14965 (AURKA_HUMAN)search. The sample contained 272 residues which is < 90% of the natural sequence. Out of 272 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AURORA-RELATED KINASE 1 O14965 (125-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 272 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (125 - 391) AURORA-RELATED KINASE 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O14965) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch