1mq1 Summary


Ca2+-S100B-TRTK-12 complex

The structure was published by McClintock, K.A. and Shaw, G.S., in 2003 in a paper entitled "A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely S-100 protein, beta chain and F-actin capping protein alpha-1 subunit.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S-100 protein, beta chain P04271 (2-92) (S100B_HUMAN)search Homo sapienssearch 99% 91 100%
B S-100 protein, beta chain P04271 (2-92) (S100B_HUMAN)search Homo sapienssearch 99% 91 100%
C F-actin capping protein alpha-1 subunit P52907 (265-276) (CAZA1_HUMAN)search Homo sapienssearch < 90% 12 100%
D F-actin capping protein alpha-1 subunit P52907 (265-276) (CAZA1_HUMAN)search Homo sapienssearch < 90% 12 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04271 (2 - 92) S-100 protein, beta chain Homo sapiens
P52907 (265 - 276) F-actin capping protein alpha-1 subunit

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P04271) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch
C, D F-actin capping protein alpha subunitsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P04271) rufflesearch extracellular regionsearch extracellular spacesearch nucleussearch cytoplasmsearch neuronal cell bodysearch intracellular membrane-bounded organellesearch perinuclear region of cytoplasmsearch receptor bindingsearch calcium ion bindingsearch protein bindingsearch zinc ion bindingsearch identical protein bindingsearch protein homodimerization activitysearch S100 protein bindingsearch metal ion bindingsearch tau protein bindingsearch calcium-dependent protein bindingsearch RAGE receptor bindingsearch axonogenesissearch central nervous system developmentsearch learning or memorysearch memorysearch cell proliferationsearch positive regulation of cell proliferationsearch regulation of cell shapesearch positive regulation of apoptotic processsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch innate immune responsesearch regulation of neuronal synaptic plasticitysearch astrocyte differentiationsearch positive regulation of synaptic transmissionsearch response to glucocorticoidsearch response to methylmercurysearch long-term synaptic potentiationsearch cellular response to hypoxiasearch negative regulation of skeletal muscle cell differentiationsearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch
C, D