1mp8 Summary

pdbe.org/1mp8
spacer

Crystal structure of Focal Adhesion Kinase (FAK)

The structure was published by Nowakowski, J., Cronin, C.N., McRee, D.E., et al., Scheibe, D.N., Swanson, R.V., and Thompson, D.A., in 2002 in a paper entitled "Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of focal adhesion kinase 1. This molecule has the UniProt identifier Q05397 (FAK1_HUMAN)search. The sample contained 281 residues which is < 90% of the natural sequence. Out of 281 residues 251 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A focal adhesion kinase 1 Q05397 (411-686) (FAK1_HUMAN)search Homo sapienssearch < 90% 281 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05397 (411 - 686) focal adhesion kinase 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q05397) protein phosphorylationsearch protein tyrosine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch