1mox Summary

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Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha

The structure was published by Garrett, T.P.J., McKern, N.M., Lou, M., et al., Nice, E.C., Burgess, A.W., and Ward, C.W., in 2002 in a paper entitled "Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor alpha" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Epidermal Growth Factor Receptor and Transforming Growth Factor alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal Growth Factor Receptor P00533 (25-525) (EGFR_HUMAN)search Homo sapienssearch < 90% 501 100%
B Epidermal Growth Factor Receptor P00533 (25-525) (EGFR_HUMAN)search Homo sapienssearch < 90% 501 100%
C Transforming Growth Factor alpha P01135 (40-89) (TGFA_HUMAN)search Homo sapienssearch < 90% 50 98%
D Transforming Growth Factor alpha P01135 (40-89) (TGFA_HUMAN)search Homo sapienssearch < 90% 50 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00533 (25 - 525) Epidermal Growth Factor Receptor Homo sapiens
P01135 (40 - 89) Transforming Growth Factor alpha Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B L domainsearch, Growth factor receptor domainsearch 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2search Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch
C, D EGF-type modulesearch Lamininsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P00533) protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch ATP bindingsearch transmembrane receptor protein tyrosine kinase activitysearch membranesearch

Chain InterPro annotation
A, B EGF receptor, L domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch
C, D Epidermal growth factor-like domainsearch EGF-like, conserved sitesearch Epidermal growth factor receptor ligandsearch