› 1mmp

X-ray diffraction
2.3Å resolution

MATRILYSIN COMPLEXED WITH CARBOXYLATE INHIBITOR

Released:
DOI: 10.2210/pdb1mmp/pdb
PDB entry 1mmp coloured by chain, front view.
PDB entry 1mmp coloured by chain, side view.
PDB entry 1mmp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Matrilysin-inhibitor complexes: common themes among metalloproteases.
Browner MF, Smith WW, Castelhano AL
Biochemistry 34 6602-10 (1995)
PMID: 7756291

Function and Biology Details

Reaction catalysed: 
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrilysin Chains: A, B
Molecule details ›
Chains: A, B
Length: 170 amino acids
Theoretical weight: 18.74 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P09237 (Residues: 95-264; Coverage: 68%)
Gene names: MMP7, MPSL1, PUMP1
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand CA 4 x CA
Ligand RSS 2 x RSS
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 62Å b: 62Å c: 175.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.18 not available
Expression system: Cricetulus griseus

Quick links

Citations

22 review citations

Matrix metalloproteinases: structures, evolution, and diversification.
Massova et al. (1998)
21 more

7 mentions without citation

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.
Khatib et al. (2002)
6 more