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PDBe Entry: 1mmk 
Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase ((FeII)) complexed with tetrahydrobiopterin and thienylalanine
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Oxidoreductase
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X-RAY DIFFRACTION
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Resolution: 2.0 Å, R-factor: 19.9%, Free R-factor: 22.9%, Spacegroup: C 2 2 21
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04/09/2003, deposition: 04/09/2002, last revision: 24/02/2009
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Andersen, O.A.; Flatmark, T.; Hough, E.
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2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding
J.MOL.BIOL. vol:333, pag:747-757 (2003) [PubMed ID 14568534 ]
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BASKET-ARRANGEMENT, 13 ALPHA-HELICES, 8 BETA-STRANDS, FERROUS IRON, Oxidoreductase
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1.14.16.1 ExPASy BRENDA (A)
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Homo sapiens(human) 9606(A)
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Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4-monooxygenase) P00439 (A)
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A
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1kw0, 1mmt, 1j8u, 1j8t
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| A |
Phenylalanine-4-hydroxylase |
Protein |
P00439 (PH4H_HUMAN)
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325 |
95% |
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| A |
FE (II) ION |
FE2
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| A |
SULFATE ION |
SO4
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| A |
5,6,7,8-TETRAHYDROBIOPTERIN |
H4B
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| A |
BETA(2-THIENYL)ALANINE |
TIH
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