1mko Summary

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A Fourth Quaternary Structure of Human Hemoglobin A at 2.18 A Resolution

The structure was published by Safo, M.K. and Abraham, D.J., in 2005 in a paper entitled "The enigma of the liganded hemoglobin end state: a novel quaternary structure of human carbonmonoxy hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.18 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch transportsearch small molecule metabolic processsearch extracellular regionsearch cytosolsearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch membranesearch
B, D (P68871) hemoglobin bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch metal ion bindingsearch heme bindingsearch iron ion bindingsearch platelet aggregationsearch positive regulation of cell deathsearch oxygen transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch bicarbonate transportsearch transportsearch hydrogen peroxide catabolic processsearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch nitric oxide transportsearch regulation of blood pressuresearch renal absorptionsearch response to hydrogen peroxidesearch oxidation-reduction processsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch