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EBI PDBe PDBeView

PDBe Entry: 1mkd view

crystal structure of PDE4D catalytic domain and zardaverine complex
Summary
Header Hydrolasesearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.9 Å, R-factor: 24.5%, Free R-factor: 26.0%, Spacegroup: P 21 21 21
Released 01/03/2003, deposition: 29/08/2002, last revision: 24/02/2009
Authors Lee, M.E.search; Markowitz, J.search; Lee, J.-O.search; Lee, H.search
Primary citation Crystal structure of phosphodiesterase 4D and inhibitor complex
FEBS LETT.search vol:530, pag:53-58 (2002) [PubMed ID 12387865 ]search
Keywords PDEsearch, Zardaverinesearch, Hydrolasesearch
EC 3.1.4.17 ExPASy BRENDA search (A B C D E F G H I J K L)
Organism Homo sapiens(human) 9606search(A B C D E F G H I J K L)
UniProt cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43) Q08499search (A B C D E F G H I J K L)
Solvent A, B, C, D, E, F, G, H, I, J, K, L
Polymers
Id Name Type UniProt Residues Observed
A, B, C, D, E, F, G, H, I, J, K, L Phosphodiesterase 4D Protein Q08499 (PDE4D_HUMAN)search
 328 100%
Heterogens
Id Name Ligands
A, B, C, D, E, F, G, H, I, J, K, L ZINC ION ZN search
A, B, C, D, E, F, G, H, I, J, K, L MAGNESIUM ION MG search
A, B, C, D, E, F, G, H, I, J, K, L 6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE ZAR search
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