1mka Summary

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E. COLI BETA-HYDROXYDECANOYL THIOL ESTER DEHYDRASE MODIFIED BY ITS CLASSIC MECHANISM-BASED INACTIVATOR, 3-DECYNOYL-N-ACETYL CYSTEAMINE

The structure was published by Leesong, M., Henderson, B.S., Gillig, J.R., Schwab, J.M., and Smith, J.L., in 1996 in a paper entitled "Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of BETA-HYDROXYDECANOYL THIOL ESTER DEHYDRASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BETA-HYDROXYDECANOYL THIOL ESTER DEHYDRASE P0A6Q3 (2-172) (FABA_ECOLI)search Escherichia coli K-12search 99% 171 100%
B BETA-HYDROXYDECANOYL THIOL ESTER DEHYDRASE P0A6Q3 (2-172) (FABA_ECOLI)search Escherichia coli K-12search 99% 171 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A6Q3 (2 - 172) BETA-HYDROXYDECANOYL THIOL ESTER DEHYDRASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P0A6Q3) beta-Hydroxydecanol thiol ester dehydrasesearch Thiol Ester Dehydrase; Chain Asearch PF07977: FabA-like domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P0A6Q3) lipid biosynthetic processsearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch lipid metabolic processsearch trans-2-decenoyl-acyl-carrier-protein isomerase activitysearch 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activitysearch lyase activitysearch 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activitysearch 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activitysearch isomerase activitysearch cytoplasmsearch

Chain InterPro annotation
A, B Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabAsearch Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZsearch HotDog domainsearch