1miu Summary

pdbe.org/1miu
spacer

Structure of a BRCA2-DSS1 complex

The structure was published by Yang, H., Jeffrey, P.D., Miller, J., et al., Chen, P.L., Lee, W.H., and Pavletich, N.P., in 2002 in a paper entitled "BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Deleted in split hand/split foot protein 1 and Breast Cancer type 2 susceptibility protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B Deleted in split hand/split foot protein 1 P60896 (1-70) (DSS1_HUMAN)search Homo sapienssearch 100% 70 60%
A Breast Cancer type 2 susceptibility protein P97929 (2378-3115) (BRCA2_MOUSE)search Mus musculussearch < 90% 738 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P60896 (1 - 70) Deleted in split hand/split foot protein 1 Homo sapiens
P97929 (2378 - 3115) Breast Cancer type 2 susceptibility protein Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
B (P60896) PF05160: DSS1/SEM1 familysearch
A BRCA2 helical domainsearch, BRCA2 tower domainsearch, Single strand DNA-binding domain, SSBsearch Nucleic acid-binding proteinssearch BRCA2, oligonucleotide/oligosaccharide-binding, domain 1search, BRCA2, oligonucleotide/oligosaccharide-binding, domain 3search, Towersearch, BRCA2, helicalsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
B (P60896) double-strand break repair via homologous recombinationsearch protein bindingsearch proteasome complexsearch integrator complexsearch
A (P97929) DNA repairsearch double-strand break repair via homologous recombinationsearch DNA recombinationsearch single-stranded DNA bindingsearch

Chain InterPro annotation
B DSS1/SEM1search
A Nucleic acid-binding, OB-foldsearch BRCA2, oligonucleotide/oligosaccharide-binding 1search BRCA2, oligonucleotide/oligosaccharide-binding 3search Towersearch Breast cancer type 2 susceptibility protein, helical domainsearch Breast cancer type 2 susceptibility proteinsearch