1mho Summary



The structure was published by Matsumura, H., Shiba, T., Inoue, T., Harada, S., and Kai, Y., in 1998 in a paper entitled "A novel mode of target recognition suggested by the 2.0 A structure of holo S100B from bovine brain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of S-100 PROTEIN. This molecule has the UniProt identifier P02638 (S100B_BOVIN)search. The sample contained 88 residues which is 96% of the natural sequence. Out of 88 residues 88 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S-100 PROTEIN P02638 (2-89) (S100B_BOVIN)search Bos taurussearch 96% 88 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02638 (2 - 89) S-100 PROTEIN Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P02638) S100 proteinssearch EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P02638) calcium-dependent protein bindingsearch protein bindingsearch protein homodimerization activitysearch tau protein bindingsearch calcium ion bindingsearch zinc ion bindingsearch S100 protein bindingsearch RAGE receptor bindingsearch metal ion bindingsearch identical protein bindingsearch kinase inhibitor activitysearch nucleussearch neuronal cell bodysearch perinuclear region of cytoplasmsearch rufflesearch cytoplasmsearch intracellular membrane-bounded organellesearch phosphorylationsearch astrocyte activationsearch regulation of neuronal synaptic plasticitysearch learning or memorysearch memorysearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch negative regulation of phosphorylationsearch axonogenesissearch regulation of translationsearch positive regulation of complement activationsearch

Chain InterPro annotation
A S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch