› 1mho

X-ray diffraction
2Å resolution

THE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN

Released:
DOI: 10.2210/pdb1mho/pdb
PDB entry 1mho coloured by chain, front view.
PDB entry 1mho coloured by chain, side view.
PDB entry 1mho coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
A novel mode of target recognition suggested by the 2.0 A structure of holo S100B from bovine brain.
Matsumura H, Shiba T, Inoue T, Harada S, Kai Y
Structure 6 233-41 (1998)
PMID: 9519413

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135973 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-B Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 10.15 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P02638 (Residues: 2-89; Coverage: 96%)
Gene name: S100B
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2221
Unit cell:
a: 36.16Å b: 89.66Å c: 58.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.286

Quick links

Citations

13 review citations

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.
Donato R. (2001)
12 more

17 mentions without citation

The evolution of S100B inhibitors for the treatment of malignant melanoma.
Hartman et al. (2013)
16 more