› 1mhn

X-ray diffraction
1.8Å resolution

High resolution crystal structure of the SMN Tudor domain

Released:
DOI: 10.2210/pdb1mhn/pdb
PDB entry 1mhn coloured by chain, front view.
PDB entry 1mhn coloured by chain, side view.
PDB entry 1mhn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues.
Sprangers R, Groves MR, Sinning I, Sattler M
J Mol Biol 327 507-20 (2003)
PMID: 12628254

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172535 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Survival motor neuron protein Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q16637 (Residues: 89-147; Coverage: 20%)
Gene names: SMN, SMN1, SMN2, SMNC, SMNT
Sequence domains: Survival motor neuron protein (SMN), Tudor domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P65
Unit cell:
a: 27.652Å b: 27.652Å c: 110.299Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.147 0.144 0.187
Expression system: Escherichia coli BL21

Quick links

Citations

34 review citations

Histone methylation: a dynamic mark in health, disease and inheritance.
Greer et al. (2012)
33 more

14 mentions without citation

What's all the phos about? Insights into the phosphorylation state of the RNA polymerase II C-terminal domain via mass spectrometry.
LeBlanc et al. (2021)
13 more