1mg5 Summary


Crystal structure of Drosophila melanogaster alcohol dehydrogenase complexed with NADH and acetate at 1.6 A

The structure was published by Benach, J., Winberg, J.O., Svendsen, J.S., Atrian, S., Gonzalez-Duarte, R., and Ladenstein, R., in 2005 in a paper entitled "Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.63 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of alcohol dehydrogenase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A alcohol dehydrogenase P00334 (2-256) (ADH_DROME)search Drosophila melanogastersearch 100% 255 100%
B alcohol dehydrogenase P00334 (2-256) (ADH_DROME)search Drosophila melanogastersearch 100% 255 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00334 (2 - 256) alcohol dehydrogenase Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P00334) Tyrosine-dependent oxidoreductasessearch NAD(P)-binding Rossmann-like Domainsearch PF00106: short chain dehydrogenasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P00334) oxidoreductase activitysearch alcohol dehydrogenase (NAD) activitysearch protein homodimerization activitysearch metabolic processsearch alcohol metabolic processsearch behavioral response to ethanolsearch oxidation-reduction processsearch alcohol catabolic processsearch microtubule associated complexsearch lipid particlesearch protein complexsearch cytosolsearch

Chain InterPro annotation
A, B Short-chain dehydrogenase/reductase SDRsearch Alcohol dehydrogenase, insect-typesearch Alcohol dehydrogenase, Drosophila-typesearch NAD(P)-binding domainsearch Short-chain dehydrogenase/reductase, conserved sitesearch