1md4 Summary

pdbe.org/1md4
spacer

A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to valine

The structure was published by Kong, G.K.-W., Polekhina, G., McKinstry, W.J., et al., Principe, D.R., Mannervik, B., and Stenberg, G., in 2003 in a paper entitled "Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of pi glutathione transferase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A pi glutathione transferase P09211 (2-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 209 99%
B pi glutathione transferase P09211 (2-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 209 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09211 (2 - 210) pi glutathione transferase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P09211) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P09211) xenobiotic metabolic processsearch common myeloid progenitor cell proliferationsearch central nervous system developmentsearch negative regulation of JUN kinase activitysearch negative regulation of I-kappaB kinase/NF-kappaB signalingsearch negative regulation of acute inflammatory responsesearch negative regulation of leukocyte proliferationsearch negative regulation of tumor necrosis factor-mediated signaling pathwaysearch negative regulation of monocyte chemotactic protein-1 productionsearch negative regulation of ERK1 and ERK2 cascadesearch metabolic processsearch glutathione metabolic processsearch negative regulation of fibroblast proliferationsearch negative regulation of extrinsic apoptotic signaling pathwaysearch negative regulation of apoptotic processsearch regulation of stress-activated MAPK cascadesearch small molecule metabolic processsearch cellular response to lipopolysaccharidesearch negative regulation of interleukin-1 beta productionsearch glutathione derivative biosynthetic processsearch negative regulation of MAPK cascadesearch negative regulation of biosynthetic processsearch positive regulation of superoxide anion generationsearch negative regulation of protein kinase activitysearch regulation of ERK1 and ERK2 cascadesearch negative regulation of tumor necrosis factor productionsearch response to reactive oxygen speciessearch nitric oxide storagesearch negative regulation of nitric-oxide synthase biosynthetic processsearch negative regulation of MAP kinase activitysearch negative regulation of stress-activated MAPK cascadesearch glutathione transferase activitysearch nitric oxide bindingsearch S-nitrosoglutathione bindingsearch protein bindingsearch JUN kinase bindingsearch dinitrosyl-iron complex bindingsearch transferase activitysearch kinase regulator activitysearch cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch mitochondrionsearch vesiclesearch intracellularsearch plasma membranesearch nucleussearch extracellular spacesearch TRAF2-GSTP1 complexsearch

Chain InterPro annotation
A, B Glutathione S-transferase, Pi classsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch