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PDBe Entry: 1mar view

REFINED 1.8 ANGSTROMS STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE POTENT INHIBITOR ZOPOLRESTAT
Summary
Header OXIDOREDUCTASE(NADP)search
Method X-RAY DIFFRACTION
Experiment Resolution: 1.8 Å, R-factor: 18.0%, Spacegroup: P 1
Released 20/07/1995, deposition: 20/07/1993, last revision: 24/02/2009
Authors Wilson, D.K.search; Quiocho, F.A.search
Primary citation Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.
PROC.NATL.ACAD.SCI.USAsearch vol:90, pag:9847-9851 (1993) [PubMed ID 8234324 ]search
Keywords OXIDOREDUCTASE(NADP)search
EC 1.1.1.21 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase) P15121search (A)
Polymers
Id Name Type UniProt Residues Observed
A ALDOSE REDUCTASE Protein P15121 (ALDR_HUMAN)search
315 100%
Heterogens
Id Name Ligands
A NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE NAP search
A 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID ZST search
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