PDB entry 1mai

STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE

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The structure was published by Ferguson, K.M., Lemmon, M.A., Schlessinger, J., and Sigler, P.B., in 1995 in a paper entitled "Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PHOSPHOLIPASE C DELTA-1. This molecule has the UniProt identifier P10688 (PLCD1_RAT). The sample contained 131 residues which is < 90% of the natural sequence. Out of 131 residues 119 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain	Name	UniProt	Name of source organism	% of UniProt sequence present in the sample	Residues in the sample molecules	% of residues observed
A	PHOSPHOLIPASE C DELTA-1	P10688 (11-140) (PLCD1_RAT)	Rattus norvegicus	< 90%	131	90%

This entry contains 1 unique UniProt protein:

UniProt accession	Name	Organism	PDB
P10688 (11 - 140)	PHOSPHOLIPASE C DELTA-1	Rattus norvegicus	Related PDB sequences UniProt coverage

Chain	Structural classification (SCOP)	Structural classification (CATH)	Sequence family (Pfam)
A	Pleckstrin-homology domain (PH domain)	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	PH domain, Phosphoinositide-specific phospholipase C, efhand-like, Phosphatidylinositol-specific phospholipase C, X domain, Phosphatidylinositol-specific phospholipase C, Y domain, C2 domain

Chain ID	Molecular function (GO)
A	Protein binding

Chain

InterPro annotation

A

C2 calcium-dependent membrane targeting, Phospholipase C, phosphatidylinositol-specific , X domain, Phosphoinositide phospholipase C, Phospholipase C, phosphatidylinositol-specific, Y domain, Pleckstrin homology domain, Calcium-binding EF-hand, C2 calcium/lipid-binding domain, CaLB, EF-hand-like domain, Pleckstrin homology-like domain, Phospholipase C, phosphoinositol-specific, EF-hand-like, PLC-like phosphodiesterase, TIM beta/alpha-barrel domain, C2 membrane targeting protein, EF-Hand 1, calcium-binding site, EF-HAND 2