1m9i Summary


Crystal Structure Of Phosphorylation-Mimicking Mutant T356D Of Annexin VI

The structure was published by Freye-Minks, C., Kretsinger, R.H., and Creutz, C.E., in 2003 in a paper entitled "Structural and Dynamic Changes in Human Annexin VI Induced by a Phosphorylation-Mimicking Mutation, T356D" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.65 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Annexin VI. This molecule has the UniProt identifier P08133 (ANXA6_HUMAN)search. The sample contained 672 residues which is 100% of the natural sequence. Out of 672 residues 664 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Annexin VI P08133 (2-673) (ANXA6_HUMAN)search Homo sapienssearch 100% 672 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08133 (2 - 673) Annexin VI Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P08133) Annexinsearch Annexin V; domain 1search PF00191: Annexinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P08133) calcium ion bindingsearch GTP bindingsearch calcium-dependent phospholipid bindingsearch calcium-dependent protein bindingsearch cholesterol bindingsearch lipid bindingsearch ligand-gated ion channel activitysearch protein bindingsearch protein homodimerization activitysearch late endosome membranesearch extracellular vesicular exosomesearch lysosomal membranesearch membranesearch focal adhesionsearch perinuclear region of cytoplasmsearch cytoplasmsearch melanosomesearch calcium ion transportsearch ion transmembrane transportsearch regulation of muscle contractionsearch protein homooligomerizationsearch

Chain InterPro annotation
A Annexinsearch Annexin, type VIsearch Annexin repeat, conserved sitesearch Annexin repeatsearch