1m7w Summary

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HNF4a ligand binding domain with bound fatty acid

The structure was published by Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y.I., and Shoelson, S.E., in 2002 in a paper entitled "Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Hepatocyte nuclear factor 4-alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hepatocyte nuclear factor 4-alpha P22449 (142-391) (HNF4A_RAT)search Rattus norvegicussearch < 90% 250 89%
B Hepatocyte nuclear factor 4-alpha P22449 (142-391) (HNF4A_RAT)search Rattus norvegicussearch < 90% 250 89%
C Hepatocyte nuclear factor 4-alpha P22449 (142-391) (HNF4A_RAT)search Rattus norvegicussearch < 90% 250 89%
D Hepatocyte nuclear factor 4-alpha P22449 (142-391) (HNF4A_RAT)search Rattus norvegicussearch < 90% 250 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22449 (142 - 391) Hepatocyte nuclear factor 4-alpha Rattus rattus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P22449) DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A, B, C, D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Transcription factor COUPsearch Nuclear hormone receptor, ligand-bindingsearch