1m7n Summary


Crystal Structure of Unactivated APO Insulin-like Growth Factor-1 Receptor Kinase Domain

The structure was published by Munshi, S., Kornienko, M., Hall, D.L., et al., Stirdivant, S.M., Darke, P.L., and Kuo, L.C., in 2002 in a paper entitled "Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Insulin-like growth factor I receptor.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin-like growth factor I receptor P08069 (974-1294) (IGF1R_HUMAN)search Homo sapienssearch < 90% 322 92%
B Insulin-like growth factor I receptor P08069 (974-1294) (IGF1R_HUMAN)search Homo sapienssearch < 90% 322 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08069 (974 - 1294) Insulin-like growth factor I receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P08069) membranesearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein kinase activitysearch ATP bindingsearch transmembrane receptor protein tyrosine kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch