1m7n Summary


Crystal Structure of Unactivated APO Insulin-like Growth Factor-1 Receptor Kinase Domain

The structure was published by Munshi, S., Kornienko, M., Hall, D.L., et al., Stirdivant, S.M., Darke, P.L., and Kuo, L.C., in 2002 in a paper entitled "Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Insulin-like growth factor I receptor.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin-like growth factor I receptor P08069 (974-1294) (IGF1R_HUMAN)search Homo sapienssearch < 90% 322 92%
B Insulin-like growth factor I receptor P08069 (974-1294) (IGF1R_HUMAN)search Homo sapienssearch < 90% 322 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08069 (974 - 1294) Insulin-like growth factor I receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P08069) transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch transmembrane receptor protein tyrosine kinase activitysearch protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch