› 1m7n

X-ray diffraction
2.7Å resolution

Crystal Structure of Unactivated APO Insulin-like Growth Factor-1 Receptor Kinase Domain

Released:
DOI: 10.2210/pdb1m7n/pdb
PDB entry 1m7n coloured by chain, front view.
PDB entry 1m7n coloured by chain, side view.
PDB entry 1m7n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity.
Munshi S, Kornienko M, Hall DL, Reid JC, Waxman L, Stirdivant SM, Darke PL, Kuo LC
J Biol Chem 277 38797-802 (2002)
PMID: 12138114

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 36.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08069 (Residues: 974-1294; Coverage: 24%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 52.88Å b: 78.06Å c: 78.97Å
α: 90° β: 99.17° γ: 90°
R-values:
R R work R free
0.229 0.229 0.294
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

The insulin-like growth factor system and cancer.
LeRoith et al. (2003)
7 more

4 mentions without citation

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR-IGF1R hybrid receptor modulators.
Turvey et al. (2022)
3 more