1m61 Summary

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Crystal structure of the apo SH2 domains of ZAP-70

The structure was published by Folmer, R.H.A., Geschwindner, S., and Xue, Y., in 2002 in a paper entitled "Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of TYROSINE-PROTEIN KINASE ZAP-70. This molecule has the UniProt identifier P43403 (ZAP70_HUMAN)search. The sample contained 259 residues which is < 90% of the natural sequence. Out of 259 residues 259 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE ZAP-70 P43403 (1-256) (ZAP70_HUMAN)search Homo sapienssearch 98% 259 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P43403 (1 - 256) TYROSINE-PROTEIN KINASE ZAP-70 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P43403) SH2 domainsearch SHC Adaptor Proteinsearch, Syk Kinase; Chain A, domain 2search PF00017: SH2 domainsearch

Chain ID Molecular function (GO)
A (P43403) non-membrane spanning protein tyrosine kinase activitysearch

Chain InterPro annotation
A SH2 domainsearch Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domainsearch