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Crystal structure of the apo SH2 domains of ZAP-70

X-ray diffraction
2.5Å resolution
PDB entry 1m61 coloured by chain, front view.
PDB entry 1m61 coloured by chain, side view.
PDB entry 1m61 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase ZAP-70
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Multimeric state: monomeric
Accessible surface area: 13031.38 Å2
Buried surface area: 213.34 Å2
Dissociation area: 106.67 Å2
Dissociation energy (ΔGdiss): 7.53 kcal/mol
Dissociation entropy (TΔSdiss): 0.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155055

Macromolecules

Tyrosine-protein kinase ZAP-70
Chain: A
Length: 259 amino acids
Theoretical weight: 29.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P43403 (Residues: 1-256; Coverage: 41%)
Gene names: SRK, ZAP70
Pfam: SH2 domain
InterPro:
CATH:
SCOP: SH2 domain
Tyrosine-protein kinase ZAP-70 in PDB entry 1m61, assembly 1, front view.
Tyrosine-protein kinase ZAP-70 in PDB entry 1m61, assembly 1, side view.
Tyrosine-protein kinase ZAP-70 in PDB entry 1m61, assembly 1, top view.
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