1m5a Summary

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Crystal Structure of 2-Co(2+)-Insulin at 1.2A Resolution

The structure was published by Nicholson, J.M., Perkins, L.C., and Korber, F.C., in 2006 in a paper entitled "The high-resolution structure of hexameric T6 cobalt insulin: A possible pathway for the T to R transition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.2 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN A CHAIN and INSULIN B CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN A CHAIN P01315 (88-108) (INS_PIG)search Sus scrofasearch < 90% 21 100%
C INSULIN A CHAIN P01315 (88-108) (INS_PIG)search Sus scrofasearch < 90% 21 100%
B INSULIN B CHAIN P01315 (25-54) (INS_PIG)search Sus scrofasearch < 90% 30 100%
D INSULIN B CHAIN P01315 (25-54) (INS_PIG)search Sus scrofasearch < 90% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01315 (88 - 108) INSULIN A CHAIN Sus scrofa

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C Insulin-likesearch Insulin/IGF/Relaxin familysearch
B, D Insulin-likesearch Insulin/IGF/Relaxin familysearch

Chain ID Molecular function (GO) Cellular component (GO)
A, C (P01315) hormone activitysearch extracellular regionsearch
B, D (P01315) hormone activitysearch extracellular regionsearch

Chain InterPro annotation
A, C Insulin-likesearch Insulin, conserved sitesearch
B, D Insulinsearch Insulin-likesearch