1m52 Summary

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Crystal Structure of the c-Abl Kinase domain in complex with PD173955

The structure was published by Nagar, B., Bornmann, W., Pellicena, P., et al., Miller, W.T., Clarkson, B., and Kuriyan, J., in 2002 in a paper entitled "Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571)" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 P00520 (229-515) (ABL1_MOUSE)search Mus musculussearch < 90% 293 92%
B PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 P00520 (229-515) (ABL1_MOUSE)search Mus musculussearch < 90% 293 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00520 (229 - 515) PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P00520) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch