1m4u Summary


Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

The structure was published by Groppe, J., Greenwald, J., Wiater, E., et al., Vale, W.W., Izpisua-Belmonte, J.C., and Choe, S., in 2002 in a paper entitled "Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.42 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bone Morphogenetic Protein-7 and Noggin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Bone Morphogenetic Protein-7 P18075 (293-431) (BMP7_HUMAN)search Homo sapienssearch < 90% 139 80%
A Noggin Q13253 (28-232) (NOGG_HUMAN)search Homo sapienssearch 100% 206 96%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18075 (293 - 431) Bone Morphogenetic Protein-7 Homo sapiens
Q13253 (28 - 232) Noggin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L Transforming growth factor (TGF)-betasearch Cystine-knot cytokinessearch Transforming growth factor beta like domainsearch
A (Q13253) Nogginsearch Cystine-knot cytokinessearch, Helix hairpin binsearch PF05806: Nogginsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
L (P18075) growth factor activitysearch extracellular regionsearch
A (Q13253) negative regulation of transcription from RNA polymerase II promotersearch skeletal system developmentsearch osteoblast differentiationsearch urogenital system developmentsearch ureteric bud developmentsearch in utero embryonic developmentsearch endoderm formationsearch mesoderm formationsearch epithelial to mesenchymal transitionsearch neural plate morphogenesissearch neural tube closuresearch multicellular organismal developmentsearch pattern specification processsearch nervous system developmentsearch axon guidancesearch central nervous system developmentsearch brain developmentsearch motor neuron axon guidancesearch dorsal/ventral pattern formationsearch negative regulation of gene expressionsearch spinal cord developmentsearch cell differentiation in hindbrainsearch neural tube developmentsearch pituitary gland developmentsearch cell differentiationsearch negative regulation of cell migrationsearch BMP signaling pathwaysearch regulation of BMP signaling pathwaysearch negative regulation of BMP signaling pathwaysearch somatic stem cell maintenancesearch wound healingsearch middle ear morphogenesissearch embryonic digit morphogenesissearch negative regulation of cell differentiationsearch negative regulation of osteoblast differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch axial mesoderm developmentsearch notochord morphogenesissearch anatomical structure formation involved in morphogenesissearch embryonic skeletal system developmentsearch negative regulation of astrocyte differentiationsearch mesenchymal cell differentiationsearch positive regulation of epithelial cell proliferationsearch cartilage developmentsearch negative regulation of cardiac muscle cell proliferationsearch limb developmentsearch embryonic skeletal joint morphogenesissearch negative regulation of cytokine activitysearch face morphogenesissearch negative regulation of pathway-restricted SMAD protein phosphorylationsearch lung morphogenesissearch prostatic bud formationsearch ureteric bud formationsearch fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch negative regulation of cartilage developmentsearch somite developmentsearch cellular response to BMP stimulussearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of branching involved in ureteric bud morphogenesissearch positive regulation of glomerulus developmentsearch regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch negative regulation of apoptotic signaling pathwaysearch protein bindingsearch cytokine bindingsearch protein homodimerization activitysearch extracellular regionsearch extracellular spacesearch

Chain InterPro annotation
L Transforming growth factor-beta, C-terminalsearch Inhibin, alpha subunitsearch Transforming growth factor-beta-relatedsearch Transforming growth factor beta, conserved sitesearch Cystine-knot cytokinesearch
A Nogginsearch Cystine-knot cytokinesearch