1m4u Summary


Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

The structure was published by Groppe, J., Greenwald, J., Wiater, E., et al., Vale, W.W., Izpisua-Belmonte, J.C., and Choe, S., in 2002 in a paper entitled "Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.42 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bone Morphogenetic Protein-7 and Noggin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Bone Morphogenetic Protein-7 P18075 (293-431) (BMP7_HUMAN)search Homo sapienssearch < 90% 139 80%
A Noggin Q13253 (28-232) (NOGG_HUMAN)search Homo sapienssearch 100% 206 96%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18075 (293 - 431) Bone Morphogenetic Protein-7 Homo sapiens
Q13253 (28 - 232) Noggin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L Transforming growth factor (TGF)-betasearch Cystine-knot cytokinessearch Transforming growth factor beta like domainsearch
A (Q13253) Nogginsearch Cystine-knot cytokinessearch, Helix hairpin binsearch PF05806: Nogginsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
L (P18075) extracellular regionsearch growth factor activitysearch
A (Q13253) pattern specification processsearch negative regulation of BMP signaling pathwaysearch negative regulation of pathway-restricted SMAD protein phosphorylationsearch middle ear morphogenesissearch positive regulation of branching involved in ureteric bud morphogenesissearch somatic stem cell maintenancesearch mesenchymal cell differentiationsearch pituitary gland developmentsearch epithelial to mesenchymal transitionsearch ureteric bud developmentsearch fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch skeletal system developmentsearch embryonic skeletal system developmentsearch limb developmentsearch BMP signaling pathwaysearch central nervous system developmentsearch urogenital system developmentsearch positive regulation of glomerulus developmentsearch wound healingsearch in utero embryonic developmentsearch dorsal/ventral pattern formationsearch embryonic digit morphogenesissearch positive regulation of transcription from RNA polymerase II promotersearch somite developmentsearch multicellular organismal developmentsearch negative regulation of transcription from RNA polymerase II promotersearch cartilage developmentsearch axial mesoderm developmentsearch neural tube developmentsearch notochord morphogenesissearch prostatic bud formationsearch negative regulation of gene expressionsearch negative regulation of cell migrationsearch nervous system developmentsearch positive regulation of epithelial cell proliferationsearch lung morphogenesissearch ureteric bud formationsearch negative regulation of cardiac muscle cell proliferationsearch face morphogenesissearch cell differentiationsearch negative regulation of astrocyte differentiationsearch osteoblast differentiationsearch embryonic skeletal joint morphogenesissearch cell differentiation in hindbrainsearch negative regulation of cytokine activitysearch cellular response to BMP stimulussearch neural plate morphogenesissearch neural tube closuresearch mesoderm formationsearch negative regulation of apoptotic signaling pathwaysearch axon guidancesearch negative regulation of osteoblast differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch endoderm formationsearch anatomical structure formation involved in morphogenesissearch motor neuron axon guidancesearch regulation of BMP signaling pathwaysearch regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch negative regulation of cell differentiationsearch negative regulation of cartilage developmentsearch spinal cord developmentsearch brain developmentsearch extracellular regionsearch extracellular spacesearch protein homodimerization activitysearch protein bindingsearch cytokine bindingsearch

Chain InterPro annotation
L Transforming growth factor-beta, C-terminalsearch Inhibin, alpha subunitsearch Transforming growth factor-beta-relatedsearch Transforming growth factor beta, conserved sitesearch Cystine-knot cytokinesearch
A Nogginsearch Cystine-knot cytokinesearch