1m4u Summary


Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

The structure was published by Groppe, J., Greenwald, J., Wiater, E., et al., Vale, W.W., Izpisua-Belmonte, J.C., and Choe, S., in 2002 in a paper entitled "Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.42 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bone Morphogenetic Protein-7 and Noggin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Bone Morphogenetic Protein-7 P18075 (293-431) (BMP7_HUMAN)search Homo sapienssearch < 90% 139 80%
A Noggin Q13253 (28-232) (NOGG_HUMAN)search Homo sapienssearch 100% 206 96%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18075 (293 - 431) Bone Morphogenetic Protein-7 Homo sapiens
Q13253 (28 - 232) Noggin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L Transforming growth factor (TGF)-betasearch Cystine-knot cytokinessearch Transforming growth factor beta like domainsearch
A (Q13253) Nogginsearch Cystine-knot cytokinessearch, Helix hairpin binsearch PF05806: Nogginsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
L (P18075) extracellular regionsearch growth factor activitysearch
A (Q13253) axon guidancesearch negative regulation of BMP signaling pathwaysearch epithelial to mesenchymal transitionsearch negative regulation of astrocyte differentiationsearch in utero embryonic developmentsearch embryonic skeletal system developmentsearch limb developmentsearch BMP signaling pathwaysearch pattern specification processsearch ureteric bud formationsearch fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch endoderm formationsearch face morphogenesissearch motor neuron axon guidancesearch dorsal/ventral pattern formationsearch embryonic digit morphogenesissearch spinal cord developmentsearch negative regulation of apoptotic signaling pathwaysearch negative regulation of gene expressionsearch axial mesoderm developmentsearch middle ear morphogenesissearch regulation of BMP signaling pathwaysearch positive regulation of branching involved in ureteric bud morphogenesissearch somatic stem cell maintenancesearch negative regulation of pathway-restricted SMAD protein phosphorylationsearch prostatic bud formationsearch mesoderm formationsearch negative regulation of cell migrationsearch nervous system developmentsearch mesenchymal cell differentiationsearch central nervous system developmentsearch neural tube developmentsearch notochord morphogenesissearch cartilage developmentsearch pituitary gland developmentsearch positive regulation of epithelial cell proliferationsearch cellular response to BMP stimulussearch osteoblast differentiationsearch cell differentiation in hindbrainsearch negative regulation of cytokine activitysearch skeletal system developmentsearch brain developmentsearch positive regulation of glomerulus developmentsearch negative regulation of transcription from RNA polymerase II promotersearch somite developmentsearch wound healingsearch positive regulation of transcription from RNA polymerase II promotersearch ureteric bud developmentsearch urogenital system developmentsearch negative regulation of cardiac muscle cell proliferationsearch lung morphogenesissearch embryonic skeletal joint morphogenesissearch cell differentiationsearch anatomical structure formation involved in morphogenesissearch multicellular organismal developmentsearch neural plate morphogenesissearch negative regulation of cartilage developmentsearch negative regulation of canonical Wnt signaling pathwaysearch regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch negative regulation of osteoblast differentiationsearch neural tube closuresearch negative regulation of cell differentiationsearch extracellular spacesearch extracellular regionsearch protein bindingsearch protein homodimerization activitysearch cytokine bindingsearch

Chain InterPro annotation
L Transforming growth factor-beta, C-terminalsearch Inhibin, alpha subunitsearch Transforming growth factor-beta-relatedsearch Transforming growth factor beta, conserved sitesearch Cystine-knot cytokinesearch
A Nogginsearch Cystine-knot cytokinesearch