1m4u Summary

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Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

The structure was published by Groppe, J., Greenwald, J., Wiater, E., et al., Vale, W.W., Izpisua-Belmonte, J.C., and Choe, S., in 2002 in a paper entitled "Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.42 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bone Morphogenetic Protein-7 and Noggin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Bone Morphogenetic Protein-7 P18075 (293-431) (BMP7_HUMAN)search Homo sapienssearch < 90% 139 80%
A Noggin Q13253 (28-232) (NOGG_HUMAN)search Homo sapienssearch 100% 206 96%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18075 (293 - 431) Bone Morphogenetic Protein-7 Homo sapiens
Q13253 (28 - 232) Noggin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L Transforming growth factor (TGF)-betasearch Cystine-knot cytokinessearch Transforming growth factor beta like domainsearch
A (Q13253) Nogginsearch Cystine-knot cytokinessearch, Helix hairpin binsearch PF05806: Nogginsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
L (P18075) extracellular regionsearch growth factor activitysearch
A (Q13253) anatomical structure formation involved in morphogenesissearch negative regulation of astrocyte differentiationsearch axial mesoderm developmentsearch negative regulation of BMP signaling pathwaysearch neural tube developmentsearch epithelial to mesenchymal transitionsearch endoderm formationsearch negative regulation of transcription from RNA polymerase II promotersearch BMP signaling pathwaysearch somite developmentsearch pituitary gland developmentsearch fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch notochord morphogenesissearch negative regulation of cardiac muscle cell proliferationsearch prostatic bud formationsearch positive regulation of branching involved in ureteric bud morphogenesissearch somatic stem cell maintenancesearch motor neuron axon guidancesearch middle ear morphogenesissearch negative regulation of pathway-restricted SMAD protein phosphorylationsearch spinal cord developmentsearch embryonic skeletal system developmentsearch limb developmentsearch dorsal/ventral pattern formationsearch embryonic digit morphogenesissearch negative regulation of apoptotic signaling pathwaysearch in utero embryonic developmentsearch osteoblast differentiationsearch pattern specification processsearch positive regulation of epithelial cell proliferationsearch positive regulation of glomerulus developmentsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to BMP stimulussearch neural tube closuresearch negative regulation of cell migrationsearch nervous system developmentsearch multicellular organismal developmentsearch ureteric bud developmentsearch mesenchymal cell differentiationsearch neural plate morphogenesissearch face morphogenesissearch axon guidancesearch cell differentiationsearch mesoderm formationsearch regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch central nervous system developmentsearch ureteric bud formationsearch regulation of BMP signaling pathwaysearch negative regulation of cartilage developmentsearch embryonic skeletal joint morphogenesissearch wound healingsearch cell differentiation in hindbrainsearch negative regulation of cytokine activitysearch skeletal system developmentsearch lung morphogenesissearch urogenital system developmentsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of osteoblast differentiationsearch negative regulation of gene expressionsearch cartilage developmentsearch brain developmentsearch negative regulation of cell differentiationsearch extracellular spacesearch extracellular regionsearch protein homodimerization activitysearch protein bindingsearch cytokine bindingsearch

Chain InterPro annotation
L Transforming growth factor-beta, C-terminalsearch Inhibin, alpha subunitsearch Transforming growth factor-beta-relatedsearch Transforming growth factor beta, conserved sitesearch Cystine-knot cytokinesearch
A Nogginsearch Cystine-knot cytokinesearch