1m4u Summary


Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

The structure was published by Groppe, J., Greenwald, J., Wiater, E., et al., Vale, W.W., Izpisua-Belmonte, J.C., and Choe, S., in 2002 in a paper entitled "Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.42 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bone Morphogenetic Protein-7 and Noggin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Bone Morphogenetic Protein-7 P18075 (293-431) (BMP7_HUMAN)search Homo sapienssearch < 90% 139 80%
A Noggin Q13253 (28-232) (NOGG_HUMAN)search Homo sapienssearch 100% 206 96%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18075 (293 - 431) Bone Morphogenetic Protein-7 Homo sapiens
Q13253 (28 - 232) Noggin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L Transforming growth factor (TGF)-betasearch Cystine-knot cytokinessearch Transforming growth factor beta like domainsearch
A (Q13253) Nogginsearch Cystine-knot cytokinessearch, Helix hairpin binsearch PF05806: Nogginsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
L (P18075) extracellular regionsearch growth factor activitysearch
A (Q13253) cartilage developmentsearch urogenital system developmentsearch negative regulation of cardiac muscle cell proliferationsearch epithelial to mesenchymal transitionsearch negative regulation of astrocyte differentiationsearch negative regulation of BMP signaling pathwaysearch BMP signaling pathwaysearch negative regulation of cell differentiationsearch pituitary gland developmentsearch negative regulation of cartilage developmentsearch embryonic skeletal system developmentsearch limb developmentsearch dorsal/ventral pattern formationsearch embryonic digit morphogenesissearch fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch positive regulation of glomerulus developmentsearch brain developmentsearch notochord morphogenesissearch negative regulation of cell migrationsearch nervous system developmentsearch somite developmentsearch axon guidancesearch mesenchymal cell differentiationsearch positive regulation of branching involved in ureteric bud morphogenesissearch somatic stem cell maintenancesearch middle ear morphogenesissearch positive regulation of epithelial cell proliferationsearch negative regulation of pathway-restricted SMAD protein phosphorylationsearch spinal cord developmentsearch face morphogenesissearch embryonic skeletal joint morphogenesissearch osteoblast differentiationsearch cell differentiation in hindbrainsearch negative regulation of cytokine activitysearch negative regulation of transcription from RNA polymerase II promotersearch multicellular organismal developmentsearch endoderm formationsearch anatomical structure formation involved in morphogenesissearch neural plate morphogenesissearch pattern specification processsearch motor neuron axon guidancesearch axial mesoderm developmentsearch positive regulation of transcription from RNA polymerase II promotersearch neural tube developmentsearch ureteric bud formationsearch negative regulation of apoptotic signaling pathwaysearch mesoderm formationsearch skeletal system developmentsearch in utero embryonic developmentsearch lung morphogenesissearch wound healingsearch prostatic bud formationsearch regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch central nervous system developmentsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of osteoblast differentiationsearch neural tube closuresearch regulation of BMP signaling pathwaysearch cell differentiationsearch cellular response to BMP stimulussearch ureteric bud developmentsearch extracellular spacesearch extracellular regionsearch protein bindingsearch cytokine bindingsearch protein homodimerization activitysearch

Chain InterPro annotation
L Transforming growth factor-beta, C-terminalsearch Inhibin, alpha subunitsearch Transforming growth factor-beta-relatedsearch Transforming growth factor beta, conserved sitesearch Cystine-knot cytokinesearch
A Nogginsearch Cystine-knot cytokinesearch