1m4u Summary


Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

The structure was published by Groppe, J., Greenwald, J., Wiater, E., et al., Vale, W.W., Izpisua-Belmonte, J.C., and Choe, S., in 2002 in a paper entitled "Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.42 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bone Morphogenetic Protein-7 and Noggin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Bone Morphogenetic Protein-7 P18075 (293-431) (BMP7_HUMAN)search Homo sapienssearch < 90% 139 80%
A Noggin Q13253 (28-232) (NOGG_HUMAN)search Homo sapienssearch 100% 206 96%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18075 (293 - 431) Bone Morphogenetic Protein-7 Homo sapiens
Q13253 (28 - 232) Noggin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L Transforming growth factor (TGF)-betasearch Cystine-knot cytokinessearch Transforming growth factor beta like domainsearch
A (Q13253) Nogginsearch Cystine-knot cytokinessearch, Helix hairpin binsearch PF05806: Nogginsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
L (P18075) extracellular regionsearch growth factor activitysearch
A (Q13253) negative regulation of astrocyte differentiationsearch positive regulation of glomerulus developmentsearch axial mesoderm developmentsearch mesoderm formationsearch embryonic digit morphogenesissearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of BMP signaling pathwaysearch neural tube developmentsearch face morphogenesissearch negative regulation of cardiac muscle cell proliferationsearch negative regulation of cell differentiationsearch axon guidancesearch osteoblast differentiationsearch epithelial to mesenchymal transitionsearch lung morphogenesissearch cell differentiationsearch fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch brain developmentsearch cellular response to BMP stimulussearch BMP signaling pathwaysearch regulation of BMP signaling pathwaysearch spinal cord developmentsearch dorsal/ventral pattern formationsearch somite developmentsearch embryonic skeletal system developmentsearch central nervous system developmentsearch nervous system developmentsearch negative regulation of osteoblast differentiationsearch negative regulation of pathway-restricted SMAD protein phosphorylationsearch positive regulation of branching involved in ureteric bud morphogenesissearch negative regulation of cytokine activitysearch mesenchymal cell differentiationsearch wound healingsearch motor neuron axon guidancesearch negative regulation of apoptotic processsearch negative regulation of canonical Wnt receptor signaling pathwaysearch embryonic skeletal joint morphogenesissearch endoderm formationsearch negative regulation of cartilage developmentsearch regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationsearch ureteric bud formationsearch negative regulation of cell migrationsearch middle ear morphogenesissearch skeletal system developmentsearch somatic stem cell maintenancesearch pattern specification processsearch multicellular organismal developmentsearch notochord morphogenesissearch cell differentiation in hindbrainsearch neural tube closuresearch anatomical structure formation involved in morphogenesissearch pituitary gland developmentsearch ureteric bud developmentsearch prostatic bud formationsearch positive regulation of epithelial cell proliferationsearch cartilage developmentsearch limb developmentsearch neural plate morphogenesissearch in utero embryonic developmentsearch negative regulation of transcription from RNA polymerase II promotersearch urogenital system developmentsearch extracellular spacesearch extracellular regionsearch protein homodimerization activitysearch cytokine bindingsearch protein bindingsearch

Chain InterPro annotation
L Transforming growth factor-beta, C-terminalsearch Inhibin, alpha subunitsearch Transforming growth factor-beta-relatedsearch Transforming growth factor beta, conserved sitesearch
A Nogginsearch