1m27 Summary

pdbe.org/1m27
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Crystal structure of SAP/FynSH3/SLAM ternary complex

The structure was published by Chan, B., Lanyi, A., Song, H.K., et al., Sumegi, J., Terhorst, C., and Eck, M.J., in 2003 in a paper entitled "SAP couples Fyn to SLAM immune receptors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely SH2 domain protein 1A, Signaling lymphocytic activation molecule, and Proto-oncogene tyrosine-protein kinase FYN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SH2 domain protein 1A O60880 (1-104) (SH21A_HUMAN)search Homo sapienssearch 100% 104 100%
B Signaling lymphocytic activation molecule Q13291 (276-286) (SLAF1_HUMAN)search Homo sapienssearch < 90% 11 100%
C Proto-oncogene tyrosine-protein kinase FYN P06241 (84-144) (FYN_HUMAN)search Homo sapienssearch < 90% 61 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
O60880 (1 - 104) SH2 domain protein 1A Homo sapiens
Q13291 (276 - 286) Signaling lymphocytic activation molecule
P06241 (84 - 144) Proto-oncogene tyrosine-protein kinase FYN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (O60880) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch
B
C SH3-domainsearch SH3 Domainssearch SH3 domainsearch
Chain InterPro annotation
A SH2 domainsearch
B
C SH3 domainsearch