1m1e Summary


Beta-catenin armadillo repeat domain bound to ICAT

The structure was published by Daniels, D.L. and Weis, W.I., in 2002 in a paper entitled "ICAT inhibits Beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Beta-catenin and ICAT.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Beta-catenin Q02248 (134-671) (CTNB1_MOUSE)search Mus musculussearch < 90% 538 95%
B ICAT Q9NSA3 (1-81) (CNBP1_HUMAN)search Homo sapienssearch 93% 81 80%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q02248 (134 - 671) Beta-catenin Mus musculus
Q9NSA3 (1 - 81) ICAT Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Armadillo repeatsearch Leucine-rich Repeat Variantsearch Armadillo/beta-catenin-like repeatsearch
B (Q9NSA3) beta-catenin-interacting protein ICATsearch beta-catenin-interacting protein ICAT, Chain B, ?????domain1search PF06384: Beta-catenin-interacting protein ICATsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
B (Q9NSA3) protein bindingsearch beta-catenin bindingsearch armadillo repeat domain bindingsearch negative regulation of Wnt signaling pathwaysearch branching involved in ureteric bud morphogenesissearch negative regulation of sequence-specific DNA binding transcription factor activitysearch Wnt signaling pathwaysearch negative regulation of protein bindingsearch negative regulation of DNA bindingsearch negative regulation of transcription initiation from RNA polymerase II promotersearch regulation of vascular permeability involved in acute inflammatory responsesearch positive regulation of osteoblast differentiationsearch negative regulation of smooth muscle cell proliferationsearch positive regulation of monocyte differentiationsearch anterior/posterior pattern specificationsearch negative regulation of transcription from RNA polymerase II promotersearch negative regulation of mesenchymal cell proliferationsearch negative regulation of protein complex assemblysearch cytoplasmsearch beta-catenin destruction complexsearch nucleussearch cytosolsearch

Chain InterPro annotation
A Armadillosearch Armadillo-like helicalsearch Beta-cateninsearch Armadillo-type foldsearch
B Beta-catenin-interacting ICATsearch