1m13 Summary


Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort

The structure was published by Watkins, R.E., Maglich, J.M., Moore, L.B., et al., Lambert, M.H., Kliewer, S.A., and Redinbo, M.R., in 2003 in a paper entitled "2.1 A Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Orphan Nuclear Receptor PXR. This molecule has the UniProt identifier O75469 (NR1I2_HUMAN)search. The sample contained 316 residues which is < 90% of the natural sequence. Out of 316 residues 264 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Orphan Nuclear Receptor PXR O75469 (130-434) (NR1I2_HUMAN)search Homo sapienssearch < 90% 316 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O75469 (130 - 434) Orphan Nuclear Receptor PXR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (O75469) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch thyroid hormone receptor activitysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch