1m10 Summary


Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain

The structure was published by Huizinga, E.G., Tsuji, S., Romijn, R.A., et al., de Groot, P.G., Sixma, J.J., and Gros, P., in 2002 in a paper entitled "Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely von Willebrand Factor and Glycoprotein Ib alpha.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A von Willebrand Factor P04275 (1261-1468) (VWF_HUMAN)search Homo sapienssearch < 90% 208 95%
B Glycoprotein Ib alpha P07359 (17-306) (GP1BA_HUMAN)search Homo sapienssearch < 90% 290 92%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04275 (1261 - 1468) von Willebrand Factor Homo sapiens
P07359 (17 - 306) Glycoprotein Ib alpha Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Integrin A (or I) domainsearch Rossmann foldsearch von Willebrand factor type A domainsearch
B Ngr ectodomain-likesearch Ribonuclease Inhibitorsearch Leucine rich repeat N-terminal domainsearch, Leucine rich repeatsearch
Chain InterPro annotation
A von Willebrand factor, type Asearch
B Leucine-rich repeat-containing N-terminalsearch Cysteine-rich flanking region, C-terminalsearch Leucine-rich repeatsearch Leucine-rich repeat, typical subtypesearch