1lzv Summary


Site-Specific Mutant (Tyr7 replaced with His) of Human Carbonic Anhydrase II

The structure was published by Tu, C., Qian, M., An, H., et al., McKenna, R., Laipis, P.J., and Silverman, D.N., in 2002 in a paper entitled "Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic Anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic Anhydrase II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic Anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch bicarbonate transportsearch secretionsearch positive regulation of cellular pH reductionsearch response to organic substancesearch response to pHsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch response to zinc ionsearch morphogenesis of an epitheliumsearch kidney developmentsearch positive regulation of bone resorptionsearch response to estrogensearch regulation of anion transportsearch carbon dioxide transportsearch angiotensin-activated signaling pathwaysearch zinc ion bindingsearch metal ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch cytoplasmsearch extracellular spacesearch apical part of cellsearch cytosolsearch plasma membranesearch basolateral plasma membranesearch microvillussearch extracellular vesicular exosomesearch membranesearch axonsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch