1lya Summary

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CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN

The structure was published by Baldwin, E.T., Bhat, T.N., Gulnik, S., et al., Collins, J., Silva, A.M., and Erickson, J.W., in 1993 in a paper entitled "Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CATHEPSIN D.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CATHEPSIN D P07339 (65-161) (CATD_HUMAN)search Homo sapienssearch < 90% 97 100%
C CATHEPSIN D P07339 (65-161) (CATD_HUMAN)search Homo sapienssearch < 90% 97 100%
B CATHEPSIN D P07339 (170-410) (CATD_HUMAN)search Homo sapienssearch < 90% 241 100%
D CATHEPSIN D P07339 (170-410) (CATD_HUMAN)search Homo sapienssearch < 90% 241 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07339 (65 - 161) CATHEPSIN D Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C Pepsin-likesearch Acid Proteasessearch Eukaryotic aspartyl proteasesearch
B, D Pepsin-likesearch Acid Proteasessearch Eukaryotic aspartyl proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, C (P07339) aspartic-type endopeptidase activitysearch proteolysissearch
B, D (P07339) aspartic-type endopeptidase activitysearch proteolysissearch

Chain InterPro annotation
A, C Aspartic peptidasesearch Aspartic peptidase, active sitesearch Aspartic peptidase domainsearch
B, D Aspartic peptidasesearch Aspartic peptidase, active sitesearch Aspartic peptidase domainsearch