1lv2 Summary


Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty Acids

The structure was published by Wisely, G.B., Miller, A.B., Davis, R.G., et al., Moore, J.T., Willson, T.M., and Williams, S.P., in 2002 in a paper entitled "Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Hepatocyte nuclear factor 4-gamma. This molecule has the UniProt identifier Q14541 (HNF4G_HUMAN)search. The sample contained 229 residues which is < 90% of the natural sequence. Out of 229 residues 223 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hepatocyte nuclear factor 4-gamma Q14541 (103-328) (HNF4G_HUMAN)search Homo sapienssearch < 90% 229 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q14541 (103 - 328) Hepatocyte nuclear factor 4-gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q14541) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Transcription factor COUPsearch Nuclear hormone receptor, ligand-bindingsearch