1lug Summary

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Full Matrix Error Analysis of Carbonic Anhydrase

The structure was published by Behnke, C.A., Le Trong, I., Godden, J.W., et al., Teller, D.C., Bajorath, J., and Stenkamp, R.E., in 2010 in a paper entitled "Atomic resolution studies of carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 0.95 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Carbonic Anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic Anhydrase II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic Anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) one-carbon metabolic processsearch bicarbonate transportsearch response to pHsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch response to estrogensearch small molecule metabolic processsearch morphogenesis of an epitheliumsearch carbon dioxide transportsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of bone resorptionsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch response to zinc ionsearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch response to steroid hormonesearch kidney developmentsearch secretionsearch cytoplasmsearch microvillussearch plasma membranesearch cytosolsearch axonsearch membranesearch basolateral plasma membranesearch apical part of cellsearch extracellular vesicular exosomesearch extracellular spacesearch protein bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch zinc ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch