1lug Summary


Full Matrix Error Analysis of Carbonic Anhydrase

The structure was published by Behnke, C.A., Le Trong, I., Godden, J.W., et al., Teller, D.C., Bajorath, J., and Stenkamp, R.E., in 2010 in a paper entitled "Atomic resolution studies of carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 0.95 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Carbonic Anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic Anhydrase II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 96% 259 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic Anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch response to organic substancesearch bicarbonate transportsearch response to estrogensearch morphogenesis of an epitheliumsearch kidney developmentsearch positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch odontogenesis of dentin-containing toothsearch cellular response to fluid shear stresssearch secretionsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch regulation of anion transportsearch response to zinc ionsearch response to pHsearch angiotensin-activated signaling pathwaysearch zinc ion bindingsearch protein bindingsearch carbonate dehydratase activitysearch lyase activitysearch arylesterase activitysearch metal ion bindingsearch cytoplasmsearch myelin sheathsearch apical part of cellsearch membranesearch cytosolsearch plasma membranesearch extracellular spacesearch extracellular exosomesearch microvillussearch axonsearch basolateral plasma membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch