1luf Summary


Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation

The structure was published by Till, J.H., Becerra, M., Watty, A., et al., Neubert, T.A., Burden, S.J., and Hubbard, S.R., in 2002 in a paper entitled "Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of muscle-specific tyrosine kinase receptor musk. This molecule has the UniProt identifier Q62838 (MUSK_RAT)search. The sample contained 343 residues which is < 90% of the natural sequence. Out of 343 residues 272 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A muscle-specific tyrosine kinase receptor musk Q62838 (529-868) (MUSK_RAT)search Rattus norvegicussearch < 90% 343 80%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q62838 (529 - 868) muscle-specific tyrosine kinase receptor musk Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q62838) protein phosphorylationsearch protein tyrosine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch